If a rogue Pentagon oinker nuked Mecca, stocks would go down in anticipation of a shit-storm. Baracko might have to personally convert to Islam and donate trillions to pro-Muslim causes a la the Marshall Plan. Security would be 100x times tighter than now, but still not effective enough to contain the world reaction. International commerse would be brought down to its knees. Etc.
If Tel-Aviv gets nuked, on the other hand, the market will rally big time in anticipation of a long and profitable war. Unemployment problem solved overnight as 3,000,000 jarheads volunteer to take part in the battle of Armageddon. Spielberg would direct a movie that takes in $10 billion dollars world-wide. World supply of synthetic drugs would decline by 90%. Etc.