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Cognitive Dissident

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AP: FDA orders lower doses in prescription painkillers
« on: January 13, 2011, 05:06:03 PM »

Quote from: the article
Acetaminophen is the leading cause of liver failure in the U.S. and sends 56,000 people to the emergency room annually. About 200 of them die, and the FDA estimates 120 of those deaths are linked to prescription drugs with acetaminophen.

Just imagine if cannabis was half as dangerous as this stuff anyone can buy without a prescription.

FDA orders lower doses in prescription painkillers
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Fred

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Re: AP: FDA orders lower doses in prescription painkillers
« Reply #1 on: January 13, 2011, 07:42:46 PM »

give me street drugs anyday!  That prescription stuff is dangerous as hell!
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BonerJoe

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Re: AP: FDA orders lower doses in prescription painkillers
« Reply #2 on: January 13, 2011, 07:49:58 PM »

The government makes them put Tylenol in most pain meds. It's definetly slowly killing my dad.
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Cognitive Dissident

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Re: AP: FDA orders lower doses in prescription painkillers
« Reply #3 on: January 14, 2011, 01:04:45 PM »

I start with napraxen sodium (my doctor told me it was least risky over-the-counter, long term) and supplement with cannabis, in various forms and doses.

I understand the struggle for someone who, for various reasons, has no cannabis option.  I'm "lucky," I suppose, because once my disorder was diagnosed, I had access to cannabis.  Sadly, even when it's "available," things like the Drug-Free Workplace Act and the larger drug war culture continue to make life more difficult than it should be.

To the point, though, I saw online that some pain meds have alternatives substituting ibuprofen (maybe even napraxen sodium?) and that might be worth checking out.  Still, most pain meds are just plain evil, not only in side effects and addictive nature, but in additional things they do to the body and brain.  I guess that's why I find it so tragically ironic about that cannabis is so demonized.
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Sam Gunn (since nobody got Admiral Naismith)

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Re: AP: FDA orders lower doses in prescription painkillers
« Reply #4 on: January 15, 2011, 12:32:33 PM »

I start with napraxen sodium (my doctor told me it was least risky over-the-counter, long term) and supplement with cannabis, in various forms and doses.

I understand the struggle for someone who, for various reasons, has no cannabis option.  I'm "lucky," I suppose, because once my disorder was diagnosed, I had access to cannabis.  Sadly, even when it's "available," things like the Drug-Free Workplace Act and the larger drug war culture continue to make life more difficult than it should be.

To the point, though, I saw online that some pain meds have alternatives substituting ibuprofen (maybe even napraxen sodium?) and that might be worth checking out.  Still, most pain meds are just plain evil, not only in side effects and addictive nature, but in additional things they do to the body and brain.  I guess that's why I find it so tragically ironic about that cannabis is so demonized.
Naproxen works the best for me too.
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Bill Brasky

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Re: AP: FDA orders lower doses in prescription painkillers
« Reply #5 on: January 15, 2011, 06:43:18 PM »

Tylenol is to be avoided.
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tranced

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Re: AP: FDA orders lower doses in prescription painkillers
« Reply #6 on: January 16, 2011, 12:14:46 AM »

Tylenol has been found to be safe for most people up to 4,000mg/day.  That's basically saying 8 extra strength or 12 regulars.  The only narcotic not available without being packaged with tylenol is hydrocodone.  Tylenol is packaged with so many meds that people that aren't able to read overdose on it.  That said, over the counter naproxyn works very well for most people, motrin works pretty good for some people, last longer than tylenol but it's more likely to cause gi bleeds than tylenol.  If your in a situation where you can't control your pain without maxing out your 4gram a day ceiling of tylenol you need a pain specialist - your lortabs or vicodins or norcos just aren't cutting it.  Personally, I like to give toradol for short term severe muscle pain, skelaxin for long term issues, lidoderm patches for incisional pain post-op (this is considered off-label use, insurance won't cover it) and fentanyl patches for generalized pain.  Roxynol and dilaudid are very low, low, low on my list of favorite pain meds.
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Bill Brasky

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Re: AP: FDA orders lower doses in prescription painkillers
« Reply #7 on: January 16, 2011, 12:55:28 AM »

Tylenol has been found to be safe for most people up to 4,000mg/day. 

Not for extended periods.  Tylenol is, by far, one of the biggest hose jobs perpetrated upon modern mankind.  It is known to be a damaging agent to the liver.  But it took a generation to fully understand the scope of the dilemma.  Now, if they admit it, they have a nationwide lawsuit like none ever seen, because alll the big labs fucked up and included the generic acetaminophen as the base delivery system of their brand-name pain products before the long-term toxicity effects were known.   

What they'll eventually do is tweak the acetaminophen compound and call it "New And Improved".  And it'll metabolize properly.  And in a few years, it'll be forgotten. 
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Cognitive Dissident

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Re: AP: FDA orders lower doses in prescription painkillers
« Reply #8 on: January 16, 2011, 04:06:17 PM »

Tylenol has been found to be safe for most people up to 4,000mg/day.  

Not for extended periods.  Tylenol is, by far, one of the biggest hose jobs perpetrated upon modern mankind.  It is known to be a damaging agent to the liver.  But it took a generation to fully understand the scope of the dilemma.  Now, if they admit it, they have a nationwide lawsuit like none ever seen, because alll the big labs fucked up and included the generic acetaminophen as the base delivery system of their brand-name pain products before the long-term toxicity effects were known.  

What they'll eventually do is tweak the acetaminophen compound and call it "New And Improved".  And it'll metabolize properly.  And in a few years, it'll be forgotten.  

...and it'll be patented, so it's win/win for them...

I'm so glad the FDA is protecting us. ;-)

As for the "then you need a pain specialist" comment (that someone else made)...been there.  Done that.
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Re: AP: FDA orders lower doses in prescription painkillers
« Reply #9 on: February 15, 2011, 02:25:48 PM »

Acetaminophen is fine for moderate pain or fever for most people with normal hepatic function; However that is not everyone.  The elderly often have compromised hepatic function due to age.  Also people who use multiple medications are at risk for drug interactions.  That means that Acetaminophen may be cleared from the body more quickly (thus the dose is subtherapeutic) or more slowly (thus the dose might increase).  When blood levels of Acetaminophen are greater than what the liver can convert to an invert substance a toxic intermediate may build up can cause damage to the liver itself.  Often patients waiting for a liver transplant are drug abusers who were addicted to opioid narcotic combination products that contain Acetaminophen.  Abusers take more and more of a drug like Vicodin to get high from the hydrocodone but get dangerous levels of Acetaminophen.

As a pharmacist, I believe that addiction is a health care and social problem.  It's certainly not a legal problem.  Acetaminophen is a huge problem in health care because it's in everything and I don't believe that it needs to be in these products.  I think a reexamination by the marketplace is in order.  The FDA rules that marketplace by fear, so many patients do not get the medical help that they need.  Doctor's do not write prescriptions when they should.  Patients do not admit problems or seek help when they should. 

Don't use drugs that you don't need.
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Cognitive Dissident

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Re: AP: FDA orders lower doses in prescription painkillers
« Reply #10 on: February 16, 2011, 12:35:03 PM »

I don't particularly like the way "leading cause of liver failure" sounds.
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